![]() ![]() These direct thrombin inhibitors and direct factor Xa inhibitors block major procoagulant activities involved in the generation of a fibrin clot. Application of these new agents requires knowledge of their individual properties, dosing, risks, and benefits. Specifically, anticoagulants that directly target the enzymatic activity of thrombin and factor Xa have been developed. In recent years, the search for new anticoagulants has generated novel agents for preventing and managing thromboembolic disorders. Anticoagulants include a variety of agents that inhibit one or more steps in the coagulation cascade. ![]()
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